• Rapid response

    Changing the UK COVID-19 vaccine dosing schedule

    On December 31, 2020 the four UK Chief Medical Officers (CMOs) published a statement announcing changes to the dosing schedule for the second dose of the Pfizer/BioNTech and University of Oxford/AstraZeneca vaccines. It stated that the interval between the first and second dose should be extended from 3–4 weeks to up to 12 weeks. This rapid response examines the evidence behind this decision.

  • Rapid response

    The performance of COVID-19 vaccines in clinical trials and in real world conditions

    COVID-19 vaccine roll-out started in the UK on 8 December 2020. Results from Phase 3 clinical trials have been published for all the vaccines approved for use in the UK. But how does the performance of vaccines under real world conditions differ from clinical trial results? When will we able to observe the impacts of the COVID-19 vaccination programme?

  • Rapid response

    Mass testing for COVID-19: January update on lateral flow tests

    The Government’s COVID-19 Winter Plan, relies on three things to provide the UK with a “route back to normality”: vaccines, treatments and testing. In addition to laboratory-based tests, lateral flow tests are being used for rapid testing in communities and workplaces. What are the latest data on how good these tests are? What are the pros and cons of using them for mass testing?

  • Rapid response

    Manufacturing COVID-19 vaccines

    The rapid production of safe, effective and consistent vaccines is essential for supporting COVID-19 immunisation programmes in the UK and globally. However, manufacturing vaccines is challenging for various reasons that include the complex processes involved, the specialist knowledge and experience required, and the natural variability of the biological materials and systems used. Urgent demand is leading to manufacturers and governments taking on significant financial risks in order to speed up production. What is the UK Government doing to accelerate vaccine manufacture? How are vaccines made? Why is manufacturing vaccines at large scales so challenging?

  • Rapid response

    COVID-19 and the digital divide

    The digital divide is the gap between people in society who have full access to digital technologies (such as the internet and computers) and those who do not. Concerns about the digital divide have been particularly acute during the COVID-19 pandemic as the internet and digital devices have played an important role in allowing people to access services, attend medical appointments and stay in touch with friends and family. What impact has the digital divide had on children and adults in the UK during the COVID-19 pandemic and what has been done to tackle it?

  • Rapid response

    Monitoring wastewater for COVID-19

    Since early 2020, the UK has been carrying out wastewater monitoring for COVID-19. Wastewater samples are collected regularly across the country and analysed for SARS-CoV-2, the virus that causes COVID-19. Wastewater monitoring is part of monitoring systems to detect new COVID-19 outbreaks and support test and trace approaches. How can SARS-CoV-2 be detected in wastewater? How can wastewater monitoring be used as part of the response to the COVID-19 outbreak? And how are wastewater monitoring programmes being used across the UK and worldwide?

  • POSTnote

    Mental health impacts of COVID-19 on NHS staff

    Media headlines have predicted an increase in mental ill health among NHS staff during the COVID-19 pandemic. This POSTnote gives an overview of the scale and quality of current evidence on the mental health and well-being of NHS staff before and during the pandemic. It also discusses how staff are supported and the options for introducing other effective interventions as the pandemic continues.

  • Rapid response

    Mass testing for COVID-19 using lateral flow tests

    The COVID-19 Winter Plan, published 23 November, relies on three factors to provide the UK with a “route back to normality”: vaccines, treatments and testing. In addition to PCR testing, lateral flow devices are now being rolled out across England and Wales for the rapid testing of certain occupational groups, community testing and as an alternative to self-isolation following exposure to the virus. How well validated have these tests been? Are they accurate enough for their proposed purposes? And how have they performed to date in mass testing trials?

  • Rapid response

    Technology and domestic abuse

    The use of technology to perpetrate domestic abuse, referred to as tech abuse, has become increasingly common. Domestic abuse charity Refuge reported that in 2019, 72% of women accessing its services said that they had been subjected to technology-facilitated abuse. Common devices such as smartphones and tablets can be misused to stalk, harass, impersonate and threaten victims. Some groups have raised concerns that the growing use of internet-connected home devices (such as smart speakers) may provide perpetrators with a wider and more sophisticated range of tools to harm victims. How is technology being used to perpetrate domestic abuse, how can this be prevented and what role can technology play in supporting victims?